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Diphenhydramine, is the active drug in Benadryl that is safe for canines.

Updated: Dec 8, 2020

Benadryl is an over-the-counter antihistamine that calms allergic reactions to environmental allergens, insect bites or stings, and certain vaccine reactions. Though it is a human drug and not FDA approved for canines and other animals, it can be given safely with approval from your vet.


Benadryl is the brand name, not the name of the drug that treats allergies. There are many other brands that make similar products, and there are other drugs under the Benadryl brand that you must use CAUTION TO AVOID.


READ the ingredients of the medication BEFORE giving it to your dog. Diphenhydramine is the active drug in Benadryl that is safe for canines. The ingredients in the pill or Caplet is xylitol, TOXIC to dogs and the liquid form contains alcohol, which is also TOXIC for dogs. Cetirizine may also be present, and while it may be safe, there is no need to expose your dog to it if it isn’t necessary. Though it is hard to find, look for the “old” style of capsule that you can open and place the beads in food. Some products also contain Acetaminophen and Pseudophedrine, which are not safe for dogs. Do not use these products, as they are TOXIC


The general dosage guideline for dogs is 1mg of Benadryl for every one pound of body weight. You start out with the smallest dose to see if benefits can be reached. You should always consult your veterinarian, as there are a number of factors that can change this dosage recommendation.

As always, Follow your vet’s guidance.

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