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Diphenhydramine hydrochloride, is the generic form for Benedryl. It’s an antihistamine, which means it reduces the effects of excess histamines in the body. We use it to treat things like insect stings, vaccine reactions, or other allergic reactions in dogs and we often recommend Benadryl for dogs suffering from mast cell tumors.
Dogs with cancer are not experiencing allergies. Hmmm, let’s comprehend this theory?
There are similarity’s between a dog with a high mast cell burden and a dog experiencing allergic flare-ups, Benedryl would address this, as Benedryl is an anti-histamine.
Mast cells can be very interesting cells, as they are part of the immune system and a type of white blood cell. They are very interesting as they rid the body of foreign invaders or material, but they can also help in healing.
Mast cells are histamines at work. However, if your body has a rapid response, or allergies, these cells can overwork, because of food, toys, environment, etc. Thus why needing the antihistamine, Benedryl.
Why do you need Tagamet with Benedryl??
Cimetidine, is the generic form of the brand name drug Tagamet.
Cimetidine is often used to treat and prevent ulcer formations in the pet’s intestine and stomach. It works to adjust the pH balance in the stomach by blocking the histamine-2 receptor.
Cimetidine is also known as histamine a2 antagonist, as it reduces acid formation in the stomach. Although it may not be beneficial to pets with high-grade cancer, it can help to reduce the effects of mast cells on the gastrointestinal tract.
Cimetidine works through several mechanisms of action, preventing immune suppression caused by tumor secretion of histamine, halting cancer growth, preventing angiogenesis, promoting cancer cell death, and averting often-fatal cancer metastasis.
Histamine is food to a cancer cell. The anticancer effect of cimetidine seems to be in its antihistamine properties which rob cancer cells of the nutrition they need to survive.
Benedryl and Tagamet work together as a team. Your alternative to chemotherapy. This protocol does not get changed or altered and is not used in conjunction with other methods, prescriptions, including CBD and some foods.
Please follow the instructions on the chart, and questions and or follow the attached link for further details and continuous follow up.
